The artist has donated the entirety of his £25,000 honor prize money to the trust for venues, which works to preserve the United Kingdom's independent live music spots.
He was given the award on 16 October as his third album his work was declared the top album of the past year.
He has decided to hand the money over to the MVT, in recognition of the crucial part small stages had in his early career.
"I personally couldn't be pursuing my current career if it hadn't been for all the gigs I performed around the area, and further afield, when I was just getting going," stated the artist. "These spaces are renowned, but they are facing challenges."
From early 2023 onward, more than 150 of these spaces have permanently closed – about 16 percent of the total UK scene.
Over the past year, major artists such as the band Pulp, the group Coldplay, the singer Katy Perry and Ed Sheeran have all backed the trust in its initiatives to support the industry, by including a small levy to their admission fees, which benefits independent venues.
Fender also joined in, collecting in excess of £100,000 on his recent tour to support thirty-eight small stages across the UK.
The money helped spaces that were facing possible closure due to issues arising from water damage, fire incidents and personal losses, as well as permit problems, conflicts and sound issues.
Additional spaces received monetary aid in upgrading infrastructure and sound and lighting systems that positively impacted musicians and concertgoers.
"The idea that money from concerts in large arenas backs the local stages, where it all starts for performers like me, is just common sense," Sam Fender has said.
He is not the first artist to donate his Mercury Prize winnings to charitable organizations.
Back when they received the prize in the year 1996 for their album the album, lead singer Jarvis Cocker declared that the band would give their prize money to the non-profit the charity.
That year, rapper and singer the artist shared her prize between multiple charities, including the NSPCC and a Sickle Cell charity.
"Additionally, I contributed a grand to my local community centre, to their gymnastics program, because I trained in gymnastics when I was a child and they needed better apparatus," she shared with a publication.
In recent years, they contributed their funds to the community center that nurtured their act, alongside other grassroots music organisations.
And 1994 winners the group gave their prize to a MS organization after a friend was identified with the disease.
"The victory was sufficient," said artist Small. "The money was the bonus but we could do without the cherry, because we had the honor. So our victory affected the lives of others."
Last week, the Music Venues Trust revealed it had saved two local spots in south-east England, by placing them under public stewardship.
One venue in that area and the other in Bristol were purchased under the public acquisition initiative, which is backed by a national body and supporters who buy "stakes" in the properties.